Normal Hematopoietic Progenitor Subsets Have Distinct Reactive Oxygen Species, BCL2 and Cell-Cycle Profiles That Are Decoupled from Maturation in Acute Myeloid Leukemia.

In acute myeloid leukemia (AML) quiescence and low oxidative state, linked to BCL2 mitochondrial regulation, endow leukemic stem cells (LSC) with treatment-resistance. LSC in CD34+ and more mature CD34- AML have heterogeneous immunophenotypes overlapping with normal stem/progenitor cells (SPC) but m...

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Autori principali:	Naeem Khan, Robert K Hills, Steve Knapper, Lora Steadman, Ushna Qureshi, Jerrald L Rector, Charlotte Bradbury, Nigel H Russell, Paresh Vyas, Alan K Burnett, David Grimwade, Paul S Hole, Sylvie D Freeman
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Public Library of Science (PLoS) 2016-01-01
Serie:	PLoS ONE
Accesso online:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0163291&type=printable
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