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Structural features of somatic and germline retrotransposition events in humans

Abstract Background Transposons are DNA sequences able to move or copy themselves to other genomic locations leading to insertional mutagenesis. Although transposon-derived sequences account for half of the human genome, most elements are no longer transposition competent. Moreover, transposons are...

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Autori principali: Päivi Nummi, Tatiana Cajuso, Tuukka Norri, Aurora Taira, Heli Kuisma, Niko Välimäki, Anna Lepistö, Laura Renkonen-Sinisalo, Selja Koskensalo, Toni T. Seppälä, Ari Ristimäki, Kyösti Tahkola, Anne Mattila, Jan Böhm, Jukka-Pekka Mecklin, Emma Siili, Annukka Pasanen, Oskari Heikinheimo, Ralf Bützow, Auli Karhu, Kathleen H. Burns, Kimmo Palin, Lauri A. Aaltonen
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2025-04-01
Serie:Mobile DNA
Soggetti:
Retrotransposition
Transposable element
L1
Colorectal cancer
Uterine leiomyoma
Long read sequencing
Accesso online:https://doi.org/10.1186/s13100-025-00357-w
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