Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP

Cholesterol homeostasis is maintained through concerted action of the SREBPs and LXRs. Here, we report that RNF145, a previously uncharacterized ER membrane ubiquitin ligase, participates in crosstalk between these critical signaling pathways. RNF145 expression is induced in response to LXR activati...

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Detalhes bibliográficos

Principais autores:	Li Zhang, Prashant Rajbhandari, Christina Priest, Jaspreet Sandhu, Xiaohui Wu, Ryan Temel, Antonio Castrillo, Thomas Q de Aguiar Vallim, Tamer Sallam, Peter Tontonoz
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2017-10-01
coleção:	eLife
Assuntos:	cholesterol LXR nuclear receptor lipid metabolism
Acesso em linha:	https://elifesciences.org/articles/28766
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