PfATP4 inhibitors in the Medicines for Malaria Venture Malaria Box and Pathogen Box block the schizont-to-ring transition by inhibiting egress rather than invasion

The cation efflux pump Plasmodium falciparum ATPase 4 (PfATP4) maintains Na+ homeostasis in malaria parasites and has been implicated in the mechanism of action of many structurally diverse antimalarial agents, including >7% of the antimalarial compounds in the Medicines for Malaria Venture’s ‘Ma...

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Hlavní autoři:	Claudia B. G. Barnes, Madeline G. Dans, Thorey K. Jonsdottir, Brendan S. Crabb, Paul R. Gilson
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2022-11-01
Edice:	Frontiers in Cellular and Infection Microbiology
Témata:	Plasmodium falciparum malaria PfATP4 sodium ions egress invasion
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fcimb.2022.1060202/full
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