CCDC174 deficiency impaired human fertility by affecting the alternative splicing of maternal mRNAs

Abstract Precise regulation of alternative splicing (AS) of maternal mRNAs is crucial for maintaining mRNA homeostasis and for acquiring oocyte competence. However, the regulatory factors and mechanisms of AS regulating oocyte competence and human fertility remain largely unknown. Here, we identifie...

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Bibliografische Detailangaben

Hauptverfasser:	Weijie Wang, Zhiqi Pan, Huixia Jing, Rong Shi, Ling Wu, Jinjie Wang, Biaobang Chen, Jian Mu, Zhihua Zhang, Tianyu Wu, Qiaoli Li, Juanzi Shi, Yanping Kuang, Lin He, Lei Wang, Qing Sang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Springer Nature 2026-05-01
Schriftenreihe:	EMBO Molecular Medicine
Online-Zugang:	https://doi.org/10.1038/s44321-026-00448-y
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