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The Crystal Structure of the Hsp90-LA1011 Complex and the Mechanism by Which LA1011 May Improve the Prognosis of Alzheimer’s Disease

Functional changes in chaperone systems play a major role in the decline of cognition and contribute to neurological pathologies, such as Alzheimer’s disease (AD). While such a decline may occur naturally with age or with stress or trauma, the mechanisms involved have remained elusive. The current m...

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Principais autores: S. Mark Roe, Zsolt Török, Andrew McGown, Ibolya Horváth, John Spencer, Tamás Pázmány, László Vigh, Chrisostomos Prodromou
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-06-01
Serier:Biomolecules
Fag:
Alzheimer’s disease
Hsp90
FKBP51
immunopilin
LA1011
co-chaperone
Online adgang:https://www.mdpi.com/2218-273X/13/7/1051
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