Structural snapshots of human DNA polymerase μ engaged on a DNA double-strand break
Polymerase μ (Polμ) participates in the repair of DNA double-strand breaks (DSBs) via the nonhomologous end-joining (NHEJ) pathway. Here, the authors determine the crystal structure of a pre-catalytic ternary complex of human Polμ with a bound DSB substrate and they obtain further mechanistic insigh...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Portfolio
2020-09-01
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| Edice: | Nature Communications |
| On-line přístup: | https://doi.org/10.1038/s41467-020-18506-5 |
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