Location of Balanced Chromosome-Translocation Breakpoints by Long-Read Sequencing on the Oxford Nanopore Platform

Genomic structural variants, including translocations, inversions, insertions, deletions, and duplications, are challenging to be reliably detected by traditional genomic technologies. In particular, balanced translocations and inversions can neither be identified by microarrays since they do not al...

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Autori principali:	Liang Hu, Fan Liang, Dehua Cheng, Zhiyuan Zhang, Guoliang Yu, Jianjun Zha, Yang Wang, Qi Xia, Daoli Yuan, Yueqiu Tan, Depeng Wang, Yu Liang, Ge Lin
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2020-01-01
Serie:	Frontiers in Genetics
Soggetti:	Oxford Nanopore Technologies structural variants balanced translocation long-read sequencing preimplantation genetic testing
Accesso online:	https://www.frontiersin.org/article/10.3389/fgene.2019.01313/full
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