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Tgfβ signaling is critical for maintenance of the tendon cell fate

Studies of cell fate focus on specification, but little is known about maintenance of the differentiated state. In this study, we find that the mouse tendon cell fate requires continuous maintenance in vivo and identify an essential role for TGFβ signaling in maintenance of the tendon cell fate. To...

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Principais autores: Guak-Kim Tan, Brian A Pryce, Anna Stabio, John V Brigande, ChaoJie Wang, Zheng Xia, Sara F Tufa, Douglas R Keene, Ronen Schweitzer
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2020-01-01
coleção:eLife
Assuntos:
tendon
TGF-beta signaling
dedifferentiation
Scleraxis
cell fate
tendon degeneration
Acesso em linha:https://elifesciences.org/articles/52695
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