Neurotoxicity of bupivacaine and liposome bupivacaine after sciatic nerve block in healthy and streptozotocin-induced diabetic mice

Abstract Background Long-acting local anaesthetics (e.g. bupivacaine hydrochloride) or sustained-release formulations of bupivacaine (e.g. liposomal bupivacaine) may be neurotoxic when applied in the setting of diabetic neuropathy. The aim of the study was to assess neurotoxicity of bupivacaine and...

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Principais autores:	Liljana Markova, Nejc Umek, Simon Horvat, Admir Hadžić, Max Kuroda, Tatjana Stopar Pintarič, Vesna Mrak, Erika Cvetko
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2020-07-01
Series:	BMC Veterinary Research
Assuntos:	Bupivacaine hydrochloride Diabetes Liposome bupivacaine injectable suspension Neurotoxicity Peripheral neuropathy
Acceso en liña:	http://link.springer.com/article/10.1186/s12917-020-02459-4
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