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Poly(pseudo)rotaxanes formed by mixed micelles and α-cyclodextrin enhance terbinafine nail permeation to deeper layers

This work aimed to develop water-based formulations for onychomycosis topical treatment using micelles of small pegylated surfactants associated with α-cyclodextrin (αCD) to deliver terbinafine to the nail. Kolliphor® RH40 (RH40) and Gelucire® 48/16 (GEL) single and mixed micelles (RH40:GEL 1:1) wer...

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Autors principals: Anna Paula Krawczyk-Santos, Ricardo Neves Marreto, Angel Concheiro, Carmen Alvarez-Lorenzo, Stephânia Fleury Taveira
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2022-12-01
Col·lecció:International Journal of Pharmaceutics: X
Matèries:
Mixed micelles
Poly(pseudo)rotaxanes
Supramolecular gels
Nail permeation
Terbinafine
Onychomycosis
Accés en línia:http://www.sciencedirect.com/science/article/pii/S259015672200007X
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