Pharmacokinetic and pharmacodynamic studies of injectable nocathiacin as a novel antibacterial agent

Abstract The extreme hydrophobicity of nocathiacin, a potent thiopeptide antibiotic against multidrug-resistant (MDR) Gram-positive pathogens, has limited its clinical development. This study formulated an injectable lyophilized nocathiacin with enhanced solubility (12.59 mg/mL). In vitro testing ag...

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Detaylı Bibliyografya
Asıl Yazarlar: Xisheng Xiong, Junjian Qian, Lang Wang, Jiawei Liu, Lulu Zhang, Kai Diao, Tao Tang, Xianliang Zhang, Xuri Wu, Yijun Chen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Portfolio 2025-09-01
Seri Bilgileri:npj Antimicrobials and Resistance
Online Erişim:https://doi.org/10.1038/s44259-025-00148-6
Etiketler: Etiketle
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