MicroRNA-122 Mimic Improves Stroke Outcomes and Indirectly Inhibits NOS2 After Middle Cerebral Artery Occlusion in Rats

Aim: Our previous study demonstrated miR-122 mimic decreased NOS2 expression in blood leucocytes and improved stroke outcomes when given immediately after middle cerebral artery occlusion (MCAO) in rats. Since NOS2 is associated with neuro-inflammation in stroke and decreasing NOS2 expression alone...

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Hlavní autoři:	Bo Lv, Xiyuan Cheng, Frank R. Sharp, Bradley P. Ander, Da Zhi Liu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2018-10-01
Edice:	Frontiers in Neuroscience
Témata:	microRNA-122 (miR-122) ischemic stroke brain microvascular endothelial cells (BMVECs) inducible nitric oxide synthase (NOS2) 3′ untranslated regions (3′UTR)
On-line přístup:	https://www.frontiersin.org/article/10.3389/fnins.2018.00767/full
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