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Histone acetyltransferase NAA40 modulates acetyl-CoA levels and lipid synthesis

Abstract Background Epigenetic regulation relies on the activity of enzymes that use sentinel metabolites as cofactors to modify DNA or histone proteins. Thus, fluctuations in cellular metabolite levels have been reported to affect chromatin modifications. However, whether epigenetic modifiers also...

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Principais autores: Evelina Charidemou, Maria A. Tsiarli, Andria Theophanous, Vural Yilmaz, Chrysoula Pitsouli, Katerina Strati, Julian L. Griffin, Antonis Kirmizis
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2022-01-01
Serier:BMC Biology
Fag:
Histone acetyltransferases
NAA40
acetyl-CoA
Lipid metabolism
Epigenetics
Drosophila melanogaster
Online adgang:https://doi.org/10.1186/s12915-021-01225-8
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