UDP-glucose, cereblon-dependent proinsulin degrader
Abstract Insulin secretion is regulated in multiple steps, and one of the main steps is in the endoplasmic reticulum (ER). Here, we show that UDP-glucose induces proinsulin ubiquitination by cereblon, and uridine binds and competes for proinsulin degradation and behaves as sustainable insulin secret...
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| Principais autores: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Portfolio
2022-08-01
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| Serier: | Scientific Reports |
| Online adgang: | https://doi.org/10.1038/s41598-022-18902-5 |
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