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Exploring the inhibitory potential of the antiarrhythmic drug amiodarone against Clostridioides difficile toxins TcdA and TcdB

ABSTRACTThe intestinal pathogen Clostridioides difficile is the leading cause of antibiotic-associated diarrhea and pseudomembranous colitis in humans. The symptoms of C. difficile-associated diseases (CDADs) are directly associated with the pathogen’s toxins TcdA and TcdB, which enter host cells an...

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Principais autores: Judith Schumacher, Astrid Nienhaus, Sebastian Heber, Jauheni Matylitsky, Esteban Chaves-Olarte, César Rodríguez, Holger Barth, Panagiotis Papatheodorou
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis Group 2023-12-01
Serier:Gut Microbes
Fag:
Clostridioides difficile infection
toxin inhibitor
membrane cholesterol
drug repurposing
drug repositioning
Online adgang:https://www.tandfonline.com/doi/10.1080/19490976.2023.2256695
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