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Mechanistic Exploration of <i>N</i>,<i>N′</i>-Disubstituted Diamines as Promising Chagas Disease Treatments

<b>Introduction:</b> Chagas disease, caused by the protozoan <i>Trypanosoma cruzi</i>, remains a major public health concern due to the limited effectiveness of current treatments, especially in the chronic stage. <b>Objective:</b> Here, we wanted to advance a library of 30 <i>N</i>,<i>N′</i>-disubs...

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Main Authors: Alejandro I. Recio-Balsells, Chantal Reigada, María Gabriela Mediavilla, Esteban Panozzo-Zénere, Miguel Villarreal Parra, Patricia S. Doyle, Juan C. Engel, Claudio A. Pereira, Julia A. Cricco, Guillermo R. Labadie
Format: Artigo
Language:Inglês
Published: MDPI AG 2026-01-01
Series:Pharmaceuticals
Subjects:
neglected diseases
Chagas disease
amastigote inhibition
polyamine transport
disubstituted diamines
Online Access:https://www.mdpi.com/1424-8247/19/1/119
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