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Recurrent adamantinomatous craniopharyngiomas show MAPK pathway activation, clonal evolution and rare TP53-loss-mediated malignant progression

Abstract The two types of craniopharyngioma, adamantinomatous (ACP) and papillary (PCP), are clinically relevant tumours in children and adults. Although the biology of primary craniopharyngioma is starting to be unravelled, little is known about the biology of recurrence. To fill this gap in knowle...

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Principais autores: John R. Apps, Jose Mario Gonzalez-Meljem, Romain Guiho, Jessica C. Pickles, Eric Prince, Edward Schwalbe, Nikhil Joshi, Thomas J. Stone, Olumide Ogunbiyi, Jane Chalker, Akang Bassey, Georg Otto, Rosalind Davies, Debbie Hughes, Sebastian Brandner, Enrica Tan, Victoria Lee, Caroline Hayhurst, Cassie Kline, Sergi Castellano, Todd Hankinson, Timo Deutschbein, Thomas S. Jacques, Juan Pedro Martinez-Barbera
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-08-01
Serier:Acta Neuropathologica Communications
Fag:
Craniopharyngioma
MAPK signalling pathway
MEK inhibitor
Macrophage/microglia
Online adgang:https://doi.org/10.1186/s40478-024-01838-4
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