Effects of 5-azacytidine on natural killer cell activating receptor expression in patients with refractory anemia with excess of blasts

Epigenetic drugs modify DNA methylation and are used in refractory anemia with excess of blasts (RAEB). These drugs may reactivate anti-oncogene expression and restore a normal phenotype instead of inducing antitumor toxicity, although they also have immunosuppressive effects on T-lymphocytes [1] In...

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Principais autores:	Régis T. Costello, Amélie Leclercq, Thérèse Le Treut, Carole Sanchez, Delphine Mercier, Gérard Sébahoun
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2015-01-01
Series:	Leukemia Research Reports
Assuntos:	Natural killer cells Refractory anemia with excess of blasts Natural cytotoxicity receptors Demethylation 5-azacytidine
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2213048915000023
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