Inhibition of insulin degrading enzyme suppresses osteoclast hyperactivity via enhancing Nrf2-dependent antioxidant response in glucocorticoid-induced osteonecrosis of the femoral head

Abstract Background Osteoclast hyperactivation due to the pathological overproduction of reactive oxygen species (ROS) stimulated by glucocorticoids (GCs) is one of the key drivers behind glucocorticoid-induced osteonecrosis of the femoral head (GIONFH). The insulin degrading enzyme (IDE), a conserv...

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Bibliographic Details

Main Authors:	Tao Yuan, Haojue Wang, Yi Wang, Shankun Dong, Jianxun Ge, Ziqing Li, Shui Sun
Format:	Artigo
Language:	Inglês
Published:	BMC 2024-07-01
Series:	Molecular Medicine
Subjects:	Glucocorticoid-induced osteonecrosis of the femoral head (GIONFH) Insulin degrading enzyme (IDE) Osteoclast Glucocorticoids (GCs) Reactive oxygen species (ROS)
Online Access:	https://doi.org/10.1186/s10020-024-00880-1
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