Accelerated accumulation of retinal α-synuclein (pSer129) and tau, neuroinflammation, and autophagic dysregulation in a seeded mouse model of Parkinson's disease

Parkinson's disease (PD) is a neurodegenerative disorder characterized by accumulation of misfolded α-synuclein within the central nervous system (CNS). Visual problems in PD patients are common, although retinal pathology associated with PD is not well understood. The purpose of this study was to i...

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主要な著者:	Najiba Mammadova, Corey M. Summers, Robyn D. Kokemuller, Qing He, Shaowei Ding, Thierry Baron, Chenxu Yu, Rudy J. Valentine, Donald S. Sakaguchi, Anumantha G. Kanthasamy, Justin J. Greenlee, M. Heather West Greenlee
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2019-01-01
シリーズ:	Neurobiology of Disease
主題:	Retina in Parkinson's Disease Photoreceptor cell loss Tau in retina Microglial activation in retina Müller glial activation Misfolded α-synuclein
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S0969996118302043
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