Potassium KCa3.1 channel overexpression deteriorates functionality and availability of channels at the outer cellular membrane

Abstract The engineered expression of K+ channels has been proposed as a potential treatment for epilepsy due to their exceptional ability to hyperpolarize neurons. A number of rodent models of gene therapy have yielded promising outcomes. However, the prevailing viral delivery methods for transgene...

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Váldodahkkit:	Natalia V. Bal, Ilya Oblasov, Victor N. Ierusalimsky, Anastasya M. Shvadchenko, Polina Fortygina, Olga S. Idzhilova, Anastasia A. Borodinova, Pavel M. Balaban, Alexey V. Feofanov, Oksana V. Nekrasova, Evgeny S. Nikitin
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Nature Portfolio 2025-02-01
Ráidu:	Scientific Reports
Fáttát:	Potassium channels Neuron Gene therapy Overexpression KCa3.1 KCNN4
Liŋkkat:	https://doi.org/10.1038/s41598-025-89097-8
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