Prophylactic NAC promoted hematopoietic reconstitution by improving endothelial cells after haploidentical HSCT: a phase 3, open-label randomized trial

Abstract Background Poor graft function (PGF) or prolonged isolated thrombocytopenia (PT), which are characterized by pancytopenia or thrombocytopenia, have become serious complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Our previous single-arm trial suggests that...

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Hlavní autoři:	Yu Wang, Yuan Kong, Hong-Yan Zhao, Yuan-Yuan Zhang, Ya-Zhe Wang, Lan-Ping Xu, Xiao-Hui Zhang, Kai-Yan Liu, Xiao-Jun Huang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2022-04-01
Edice:	BMC Medicine
Témata:	N-Acetyl-L-cysteine Poor hematopoietic reconstitution Allogeneic hematopoietic stem cell transplantation Endothelial cells Bone marrow microenvironment
On-line přístup:	https://doi.org/10.1186/s12916-022-02338-9
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