Silicone substrate topography modulates fibroblast-to-myofibroblast transition through Filamin A-mediated TGFβ/Smad signaling pathway

Capsular contracture, a prevalent complication of polydimethylsiloxane (PDMS) implants, severely compromises patients’ quality of life. While surface morphology is recognized as a PDMS-related factor influencing capsular contracture, the precise mechanism by which this physical alteration affects in...

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Автори:	Ruolan Liu, Xiaohua Shi, Dafang Yu, Yujie Lan, Yujiao Huang, Zichen Yang, Cheng Chen, Yao Chen, Linbo Jin, Dongli Fan, Zeyuan Lei
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Elsevier 2026-02-01
Серія:	Materials & Design
Предмети:	Microgrooves PDMS Capsular contracture Filamin A TGF-β/smad Fibroblast-to-myofibroblast transition
Онлайн доступ:	http://www.sciencedirect.com/science/article/pii/S026412752600078X
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