H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis
Histone modifications play important roles in gene transcription and cancer. Here the authors establish a role for the E3 ubiquitin ligase NEDD4 in modifying in a glucose-dependent manner the histone H3, thus regulating the expression of genes involved in tumorigenesis.
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| Principais autores: | , , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Portfolio
2017-03-01
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| Series: | Nature Communications |
| Acceso en liña: | https://doi.org/10.1038/ncomms14799 |
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