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Paradoxical Effect of 2,3-Dimercapto-1-propanesulfonic Acid (DMPS) on Enhancing Antitumor Activity of Cisplatin in Ascites Sarcoma 180 Cells

We investigated the enhancing effect of two metal-chelating compounds, 2,3-dimercapto-1-propanesulfonic acid (DMPS) and meso-2,3-dimercaptosuccinic acid (DMSA), on the antitumor activity of cisplatin (CDDP). In the in vivo experiments, DMPS showed a clear synergistic effect and significantly enhance...

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Principais autores: Toshihiro Sato, Migiwa Okubo, Kohei Sawaki, Hiroshi Maehashi, Mitsuru Kawaguchi
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2010-01-01
Series:Journal of Pharmacological Sciences
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S1347861319310059
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