In situ osteogenic activation of mesenchymal stem cells by the blood clot biomimetic mechanical microenvironment
Abstract Blood clots (BCs) play a crucial biomechanical role in promoting osteogenesis and regulating mesenchymal stem cell (MSC) function and fate. This study shows that BC formation enhances MSC osteogenesis by activating Itgb1/Fak-mediated focal adhesion and subsequent Runx2-mediated bone regener...
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| Hoofdauteurs: | , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Portfolio
2025-01-01
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| Reeks: | Nature Communications |
| Online toegang: | https://doi.org/10.1038/s41467-025-56513-6 |
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