Age-dependent peripheral dissemination of α-synuclein seeds: mechanistic basis for blood-based early detection of Parkinson’s disease

Abstract Early diagnosis of Parkinson’s disease (PD) before extensive neurodegeneration is a critical unmet need, largely due to the absence of sensitive, minimally or non-invasive biomarkers for the prodromal stage. Here, we primarily use α-synuclein (α-Syn) preformed fibril (PFF)-induced mouse mod...

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Autori principali:	Yaoyun Kuang, Hengxu Mao, Hao Lin, Wei Dai, Zhongqiang Su, Ying Luo, Wen-Quan Zou, Xin-ling Yang, Ping-Yi Xu
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2026-05-01
Serie:	Acta Neuropathologica Communications
Soggetti:	α-Synuclein Seed amplification assay Quiescent SAA Parkinson's disease Seeding activity
Accesso online:	https://doi.org/10.1186/s40478-026-02322-x
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