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Isoform-selective decrease of glycogen synthase kinase-3-beta (GSK-3β) reduces synaptic tau phosphorylation, transcellular spreading, and aggregation

Summary: It has been suggested that aberrant activation of glycogen synthase kinase-3-beta (GSK-3β) can trigger abnormal tau hyperphosphorylation and aggregation, which ultimately leads to neuronal/synaptic damage and impaired cognition in Alzheimer disease (AD). We examined if isoform-selective par...

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Principais autores: Ana Claudia Amaral, Beatriz G. Perez-Nievas, Michael Siao Tick Chong, Alicia Gonzalez-Martinez, Herminia Argente-Escrig, Sara Rubio-Guerra, Caitlin Commins, Serra Muftu, Bahareh Eftekharzadeh, Eloise Hudry, Zhanyun Fan, Prianca Ramanan, Shuko Takeda, Matthew P. Frosch, Susanne Wegmann, Teresa Gomez-Isla
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021-02-01
Serier:iScience
Fag:
Biological Sciences
Neuroscience
Cellular Neuroscience
Online adgang:http://www.sciencedirect.com/science/article/pii/S2589004221000262
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