Osteoblast–Osteoclast Coculture Amplifies Inhibitory Effects of FG‐4592 on Human Osteoclastogenesis and Reduces Bone Resorption

ABSTRACT The link between bone and blood vessels is regulated by hypoxia and the hypoxia‐inducible transcription factor, HIF, which drives both osteogenesis and angiogenesis. The recent clinical approval of PHD enzyme inhibitors, which stabilize HIF protein, introduces the potential for a new clinic...

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Hauptverfasser:	Philippa A Hulley, Ioanna Papadimitriou‐Olivgeri, Helen J Knowles
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 2020-07-01
Schriftenreihe:	JBMR Plus
Schlagworte:	3D MODELS COCULTURE OSTEOBLASTS OSTEOCLASTS PHD ENZYME INHIBITOR
Online-Zugang:	https://doi.org/10.1002/jbm4.10370
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