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Syndecans and glycosaminoglycans influence B-cell development and activation

Abstract Syndecans (SDCs) are glycosaminoglycan-containing cell surface proteins with diverse functions in the immune system with SDC1 (CD138) and SDC4 expressed in B-lineage cells. Here, we show that stem cells lacking either molecule generate fewer B-cell progenitors but give rise to mature B cell...

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Furkejuvvon:
Váldodahkkit: Craig I McKenzie, Alexandra R Dvorscek, Zhoujie Ding, Marcus J Robinson, Kristy O’Donnell, Catherine Pitt, Daniel T Ferguson, Jesse Mulder, Marco J Herold, David M Tarlinton, Isaak Quast
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Springer Nature 2025-03-01
Ráidu:EMBO Reports
Fáttát:
B Cells
CD138
Syndecan-4
Heparin
Glycosaminoglycans
Liŋkkat:https://doi.org/10.1038/s44319-025-00432-6
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