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Evidence for a lack of inotropic and chronotropic effects of glucagon and glucagon receptors in the human heart

Abstract Background Glucagon is thought to increase heart rate and contractility by stimulating glucagon receptors and increasing 3′,5′-cyclic adenosine monophosphate (cAMP) production in the myocardium. This has been confirmed in animal studies but not in the human heart. The cardiostimulatory effe...

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Principais autores: Ramón Aranda-Domene, Esteban Orenes-Piñero, José María Arribas-Leal, Sergio Canovas-Lopez, Jesús Hernández-Cascales
Format: Artigo
Jezik:Inglês
Izdano: BMC 2023-05-01
Serija:Cardiovascular Diabetology
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Online dostop:https://doi.org/10.1186/s12933-023-01859-8
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