Reversing metabolic dysregulation in farnesoid X receptor knockout mice via gut microbiota modulation.

The farnesoid X receptor (FXR), expressed in the liver and in the small intestine, is a key regulator of glucose and lipid metabolism. Its pharmacological modulation is explored as a potential treatment for obesity-related metabolic impairments. To develop effective pharmacological interventions, it...

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Hauptverfasser:	Ines Leila Paraiso, Armando Alcázar Magaña, Alexandra Alexiev, Thomas J Sharpton, Claudia S Maier, Chrissa Kioussi, Jan F Stevens
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Public Library of Science (PLoS) 2025-01-01
Schriftenreihe:	PLoS ONE
Online-Zugang:	https://doi.org/10.1371/journal.pone.0331040
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