Gene signature associated with resistance to fluvastatin chemoprevention for breast cancer

Abstract Background Although targeting of the cholesterol pathway by statins prevents breast cancer development in mouse models, efficacy is not absolute. Therefore, the goal of this study is to investigate if the upregulation in the cholesterol biosynthesis pathway genes associates with response to...

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Hlavní autoři:	Anjana Bhardwaj, Matthew D. Embury, Zhenlin Ju, Jing Wang, Isabelle Bedrosian
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2022-03-01
Edice:	BMC Cancer
Témata:	Breast cancer prevention Statin Cholesterol biosynthesis Statin response Resistance gene signature
On-line přístup:	https://doi.org/10.1186/s12885-022-09353-2
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