MEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and JunB

Abstract Clinical evidence supports the notion that T cell exhaustion and terminal differentiation pose challenges to the persistence and effectiveness of chimeric antigen receptor-T (CAR-T) cells. MEK1/2 inhibitors (MEKIs), widely used in cancer treatment due to their ability to inhibit aberrant MA...

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主要な著者:	Xiujian Wang, Xiao Tao, Pengjie Chen, Penglei Jiang, Wenxiao Li, Hefeng Chang, Cong Wei, Xinyi Lai, Hao Zhang, Yihan Pan, Lijuan Ding, Zuyu Liang, Jiazhen Cui, Mi Shao, Xinyi Teng, Tianning Gu, Jieping Wei, Delin Kong, Xiaohui Si, Yingli Han, Huarui Fu, Yu Lin, Jian Yu, Xia Li, Dongrui Wang, Yongxian Hu, Pengxu Qian, He Huang
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Publishing Group 2024-10-01
シリーズ:	Signal Transduction and Targeted Therapy
オンライン･アクセス:	https://doi.org/10.1038/s41392-024-01986-y
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