Challenges and opportunities for oncology drug repurposing informed by synthetic lethality
Abstract Although two-thirds of cancers arise from loss-of-function mutations in tumor suppressor genes, there are few approved targeted therapies linked to these alterations. Synthetic lethality offers a promising strategy to treat such cancers by targeting vulnerabilities unique to cancer cells wi...
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| Principais autores: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Portfolio
2025-12-01
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| Series: | npj Systems Biology and Applications |
| Acceso en liña: | https://doi.org/10.1038/s41540-025-00618-7 |
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