Immunosuppressive JAG2+ tumor‐associated neutrophils hamper PD‐1 blockade response in ovarian cancer by mediating the differentiation of effector regulatory T cells

Abstract Background Tumor‐associated neutrophils (TANs) play a critical role in modulating immune responses and exhibit significant heterogeneity. Our previous study demonstrated that jagged canonical Notch ligand 2 (JAG2)+ TANs were associated with an immunosuppressive microenvironment in high‐grad...

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Autori principali:	Chenyang Wang, Moran Yang, Yujing Zhong, Kankan Cao, Xueling Wang, Chen Zhang, Yiying Wang, Mengdi He, Jiaqi Lu, Guodong Zhang, Yan Huang, Haiou Liu
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wiley 2025-07-01
Serie:	Cancer Communications
Soggetti:	effector regulatory T cells high‐grade serous ovarian cancer Jagged2 programmed cell death 1 Tumor‐associated neutrophils
Accesso online:	https://doi.org/10.1002/cac2.70021
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