Exploring Novel Pyridine Carboxamide Derivatives as Urease Inhibitors: Synthesis, Molecular Docking, Kinetic Studies and ADME Profile

The rapid development of resistance by ureolytic bacteria which are involved in various life-threatening conditions such as gastric and duodenal cancer has induced the need to develop a new line of therapy which has anti-urease activity. A series of pyridine carboxamide and carbothioamide derivative...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Ayesha Naseer, Faisal Abdulrhman Osra, Asia Naz Awan, Aqeel Imran, Abdul Hameed, Syed Adnan Ali Shah, Jamshed Iqbal, Zainul Amiruddin Zakaria
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2022-10-01
Schriftenreihe:	Pharmaceuticals
Schlagworte:	semicarbazide thiosemicarbazide semicarbazone thiosemicarbazone urease inhibition molecular docking
Online-Zugang:	https://www.mdpi.com/1424-8247/15/10/1288
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