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Molecular Mechanisms of Leukocyte Migration and Its Potential Targeting—Lessons Learned From MKL1/SRF-Related Primary Immunodeficiency Diseases

Megakaryoblastic leukemia 1 (MKL1) deficiency is one of the most recently discovered primary immunodeficiencies (PIDs) caused by cytoskeletal abnormalities. These immunological “actinopathies” primarily affect hematopoietic cells, resulting in defects in both the innate immune system (phagocyte defe...

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Hlavní autoři: Evelien G. G. Sprenkeler, Carla Guenther, Imrul Faisal, Taco W. Kuijpers, Susanna C. Fagerholm
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021-02-01
Edice:Frontiers in Immunology
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On-line přístup:https://www.frontiersin.org/articles/10.3389/fimmu.2021.615477/full
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