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The Hippo pathway terminal effector TAZ/WWTR1 mediates oxaliplatin sensitivity in p53 proficient colon cancer cells

Abstract YAP and TAZ, the Hippo pathway terminal transcriptional activators, are frequently upregulated in cancers. In tumor cells, they have been mainly associated with increased tumorigenesis controlling different aspects from cell cycle regulation, stemness, or resistance to chemotherapies. In fe...

Täydet tiedot

Tallennettuna:
Päätekijät: Věra Slaninová, Lisa Heron-Milhavet, Mathilde Robin, Laura Jeanson, Adam Aissanou, Diala Kantar, Diego Tosi, Laurent Bréhélin, Céline Gongora, Alexandre Djiane
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BMC 2024-05-01
Sarja:BMC Cancer
Aiheet:
Oxaliplatin
Colon cancer
Hippo signaling
TAZ
p53
Linkit:https://doi.org/10.1186/s12885-024-12316-4
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