Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS

Apolipoprotein (apo) E has roles beyond lipoprotein metabolism. The detrimental effects of apoE4 in cardiovascular, neurological, and infectious diseases correlate with its structural features (e.g., domain interaction) that distinguish it from apoE3 and apoE2. Structure/function studies revealed th...

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Autors principals:	Robert W. Mahley, Karl H. Weisgraber, Yadong Huang
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2009-01-01
Col·lecció:	Journal of Lipid Research
Matèries:	cholesterol neurodegeneration HIV coronary heart disease LDL receptor dysbetalipoproteinemia
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S002222752030609X
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