IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells

Summary: IL11 initiates fibroblast activation but also causes epithelial cell dysfunction. The mechanisms underlying these processes are not known. We report that IL11-stimulated ERK/P90RSK activity causes the phosphorylation of LKB1 at S325 and S428, leading to its inactivation. This inhibits AMPK...

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Detalhes bibliográficos

Principais autores:	Anissa A. Widjaja, Sivakumar Viswanathan, Joyce Goh Wei Ting, Jessie Tan, Shamini G. Shekeran, David Carling, Wei-Wen Lim, Stuart A. Cook
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2022-08-01
coleção:	iScience
Assuntos:	Cell biology Functional aspects of cell biology
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2589004222010781
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