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Interferon receptor-deficient mice are susceptible to eschar-associated rickettsiosis

Arthropod-borne rickettsial pathogens cause mild and severe human disease worldwide. The tick-borne pathogen Rickettsia parkeri elicits skin lesions (eschars) and disseminated disease in humans; however, inbred mice are generally resistant to infection. We report that intradermal infection of mice l...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Thomas P Burke, Patrik Engström, Cuong J Tran, Ingeborg M Langohr, Dustin R Glasner, Diego A Espinosa, Eva Harris, Matthew D Welch
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications Ltd 2021-08-01
Schriftenreihe:eLife
Schlagworte:
interferons
eschar-associated rickettsiosis
rickettsia
actin-based motility
type i interferon
immunity
Online-Zugang:https://elifesciences.org/articles/67029
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