U6 snRNA expression prevents toxicity in TDP-43-knockdown cells.
Depletion of amyotrophic lateral sclerosis (ALS)-associated transactivation response (TAR) RNA/DNA-binding protein 43 kDa (TDP-43) alters splicing efficiency of multiple transcripts and results in neuronal cell death. TDP-43 depletion can also disturb expression levels of small nuclear RNAs (snRNAs)...
Gardado en:
| Principais autores: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Acceso en liña: | https://doi.org/10.1371/journal.pone.0187813 |
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