Severe anaphylaxis following off-label rectal use of injectable diazepam in a febrile seizure: a case report and clinical implications

Abstract Background Off-label rectal administration of intravenous diazepam is commonly practiced for acute seizure management in children when FDA-approved rectal gels (e.g., Diastat® AcuDial) are inaccessible—particularly in low-resource settings like Vietnam. However, such injectable formulations...

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Detalhes bibliográficos

Principais autores:	Ninh Xuan Nguyen, Ngoc Tien Pham, Huong Thi Thanh Le, Quoc Viet Tran, Hang Ngoc Thuy Tran, Thi Kim Thanh Vo, Chuong Thi Ngoc Dang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-01-01
coleção:	International Journal of Emergency Medicine
Assuntos:	Febrile seizure Rectal diazepam Propylene glycol Pediatric anaphylaxis Off-label use Excipient hypersensitivity
Acesso em linha:	https://doi.org/10.1186/s12245-026-01123-2
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