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The Planar Polarity Component VANGL2 Is a Key Regulator of Mechanosignaling

VANGL2 is a component of the planar cell polarity (PCP) pathway, which regulates tissue polarity and patterning. The Vangl2Lp mutation causes lung branching defects due to dysfunctional actomyosin-driven morphogenesis. Since the actomyosin network regulates cell mechanics, we speculated that mechano...

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Autori principali: Sek-Shir Cheong, Khondoker M. Akram, Carlos Matellan, Sally Yunsun Kim, David C. A. Gaboriau, Matthew Hind, Armando E. del Río Hernández, Mark Griffiths, Charlotte H. Dean
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020-10-01
Serie:Frontiers in Cell and Developmental Biology
Soggetti:
VANGL2
planar cell polarity
mechanosignaling
cell migration
focal adhesion
traction force
Accesso online:https://www.frontiersin.org/articles/10.3389/fcell.2020.577201/full
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