Mechanistic insights of lenvatinib: enhancing cisplatin sensitivity, inducing apoptosis, and suppressing metastasis in bladder cancer cells through EGFR/ERK/P38/NF-κB signaling inactivation

Abstract Background The persistent activation of the epidermal growth factor receptor (EGFR) leads to the activation of downstream oncogenic kinases and transcription factors, resulting in tumor progression and an increased resistance to cisplatin in bladder cancer (BC) cells. Lenvatinib, an oral mu...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Chih-Hung Chiang, Jr-Di Yang, Wei-Lin Liu, Fang-Yu Chang, Che-Jui Yang, Kai-Wen Hsu, I-Tsang Chiang, Fei-Ting Hsu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-02-01
coleção:	Cancer Cell International
Assuntos:	Lenvatinib Cisplatin EGFR ERK NF-κB Bladder cancer
Acesso em linha:	https://doi.org/10.1186/s12935-024-03597-7
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!