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Hypomethylating agents increase L1 retroelement expression without inducing novel insertions in myeloid malignancies

Retroelements in the human genome are silenced via multiple mechanisms, including DNA methylation, to prevent their potential mutagenic effect. Retroelement activity, demonstrated by their expression and somatic retrotransposition events, was shown to be deregulated in multiple tumors but not yet in...

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Автори: Šárka Pavlová, Hana Svozilová, Marcela Krzyžánková, Radim Sonnek, Anastasiya Volakhava, Anastasia Smirnova, Tatiana Grigoreva, Zuzana Jašková, Hana Synáčková, Dennis Wahl, Michaela Bilčíková, Libor Červinek, Šárka Pospíšilová, Ilgar Mamedov, Karla Plevová
Формат: Artigo
Мова:Inglês
Опубліковано: Wiley 2025-10-01
Серія:Molecular Oncology
Предмети:
5′‐azacytidine
hypomethylation agent
L1
LINE‐1
myelodysplastic syndrome
ORF1p
Онлайн доступ:https://doi.org/10.1002/1878-0261.70111
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