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An ADAR1 dsRBD3-PKR kinase domain interaction on dsRNA inhibits PKR activation

Summary: Adar null mutant mouse embryos die with aberrant double-stranded RNA (dsRNA)-driven interferon induction, and Adar Mavs double mutants, in which interferon induction is prevented, die soon after birth. Protein kinase R (Pkr) is aberrantly activated in Adar Mavs mouse pup intestines before d...

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Furkejuvvon:
Váldodahkkit: Ketty Sinigaglia, Anna Cherian, Qiupei Du, Valentina Lacovich, Dragana Vukić, Janka Melicherová, Pavla Linhartova, Lisa Zerad, Stanislav Stejskal, Radek Malik, Jan Prochazka, Nadège Bondurand, Radislav Sedláček, Mary A. O’Connell, Liam P. Keegan
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Elsevier 2024-08-01
Ráidu:Cell Reports
Fáttát:
CP: Molecular biology
Liŋkkat:http://www.sciencedirect.com/science/article/pii/S2211124724009689
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