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Brd4::Nutm1 fusion gene initiates NUT carcinoma in vivo

This study developed the first GEMM for NUT carcinoma to syntenically recapitulate the t(15;19) chromosome translocation in humans, serving as a critical preclinical model for the disease. NUT carcinoma (NC) is an aggressive cancer with no effective treatment. About 70% of NUT carcinoma is associate...

Ausführliche Beschreibung

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Bibliografische Detailangaben
Hauptverfasser: Dejin Zheng, Ahmed A Elnegiry, Chenxiang Luo, Mohammed Amine Bendahou, Liangqi Xie, Diana Bell, Yoko Takahashi, Ehab Hanna, George I Mias, Mayra F Tsoi, Bin Gu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Life Science Alliance LLC 2024-07-01
Schriftenreihe:Life Science Alliance
Online-Zugang:https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202402602
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